Nephrogenic Fibrosing
Dermopathy or Nephrogenic Systemic Fibrosis (NSF)
Nephrogenic Systemic Fibrosis (NSF). Nephrogenic systemic
fibrosis resembles scleroderma and eosinophilic fasciitis
clinically and scleromyxedema histopathologically. Patients with
NSF may develop large areas of indurated skin with fibrotic
nodules and plaques. The pathophysiology of nephrogenic systemic
fibrosis is related to the exposure of patients with renal
insufficiency to gadolinium in association with imaging studies.
Noah S. Scheinfeld, MD. eMedicine. 09/16/09.
Nephrogenic systemic fibrosis (NSF): an emerging threat among
renal patients. NSF is a scleroderma-like skin disease
observed in patients with renal insufficiency. Recent
observations indicate that specific cells normally involved in
wound repair and tissue remodeling may be aberrantly recruited
to the skin and soft tissues of NSF patients. PubMed. Semin
Dial. 2006 May-Jun;19(3):191-4. (Also see:
Renal Involvement)
Bullous Pemphigoid. Bullous pemphigoid is a skin disorder
characterized by large blisters. Medline Plus.
Bullous Pemphigoid in a Patient with Systemic Sclerosis
(Scleroderma). Diagnosis of blistering skin disease like
bullous pemphigoid can be overlooked in patients with
scleroderma because significant pruritus and ulcerations are
commonly part of the scleroderma skin process. J Rheumatol
2006 October;33:2098. Letters.