| Zoloft (Sertraline)
C17H17Cl2N
Systematic (IUPAC)
name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
http://en.wikipedia.org/wiki/Sertraline
|
C17H17NCl2•HCl
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
hydrochloride. Has an FDA black box warning regarding
suicide. The
FDA approved the drug, manufactured by Pfizer, for depression in
1992, for OCD in 1996, for PMDD in 2002, and for SAD in 2003.The
mode of action of Zoloft is believed to be linked to its inhibition
of CNS neuronal uptake of
serotonin. Clinical trials at relevant doses in humans have
demonstrated that sertraline blocks the uptake of serotonin into
human platelets: tightly bound to plasma protein. Zoloft can
have a number of adverse side effects, including asthenia (a feeling
of weakness without an actual loss in strength), diarrhea, gas,
headache, indigestion, pain, rash, sore throat, tingling sensations,
vomiting, problems with vision, insomnia, gastrointestinal
disturbances, confusion, dizziness, tremors, delayed ejaculation in
men (anorgasmia), and decreased sex drive. It can induce mania or
hypomania in a small percentage of individuals. It has also been
known to cause minor weight loss.
Less common or rare side effects reported include acne, breast
pain or enlargement, fainting, double vision, dry or painful eyes,
lightheadedness when standing from a sitting or supine position,
difficulties breathing, allergic reaction, altered taste sensation,
back pain, changeable emotions, difficulty swallowing, cold clammy
skin, cataracts, chest pain, fever, fluid retention, flushing,
increased salivation, increased libido, inability to stay seated,
hearing problems, frequent urination, hair
loss, heart attack, general malaise, hot flushes, low blood
pressure, migraine, kidney failure, lack of coordination,
nasal inflammation, hemorrhoids, hiccups, glaucoma, lack of
sensation, light sensitivity, increased salivation, inflammation of
the penis, depersonalization (an “unreal” feeling), abnormal
dreams/thoughts, hallucinations, paranoia, rapid mood swings,
tooth-grinding, worsening of depressive
symptoms, memory loss,
nosebleed, increased urination at night, ringing in the ears,
racing heartbeat, rectal hemorrhage, respiratory infection,
skin inflammation or eruptions, edema of the wrists or ankles,
irregular heartbeat, twitching, yawn, sleepwalking and vaginal
hemorrhage or discharge.
In June 2003, the UK banned sertraline for use in children under
18 after studies indicated a link to increasing suicidal rates.
Similar concern has been expressed widely in the US, where only
fluoxetine (another SSRI) has been officially banned by the FDA for
treating depression in minors.
chris
pittman Source:
anxiety-and-depression-solutions.com/articles/conventional/pharmaceutical/zoloft.php |
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Norma's death was blamed on pancreatic cancer - But more probably it was the anemia doctors are in some ways aware of, but often not diagnosed: rapid heart beat, gasping for breath, ''the chills' in the last hours of life ... and signs for years before, also
