What about the hereditary link? 

My grandfather had undiagnosed Cushing's as well as my mother, that's where mine has stemmed from, I believe. My grandfather was exposed to fumes at the Railroad yard where he worked as first a switchman than up to General Manager.

My mother used to visit him there regularly, however I did not. I could see him contracting something like Cushing's from his exposure to the fumes from the Railroad cars and engines, but what about me who has never really been exposed to much the last few years?   Mari

 

Was grandpa exposed prior to your mother's conception? If so ... or if he was being exposed during the pregnancy & after your mom's birth ... she could get the exposure 'second hand' If prior to conception it would be from the fact that this is one of the teratogen chemicals ... meaning it harms the developing fetus. It also causes reproductive harm for those affected if they get more exposure & are unable to have a child ... or loose interest in sex altogether (Men might have zero sperm & ED problems) Part of an endocrine issue. The autoimmune thing to consider for men is spontaneous infertility in which the immune system attacks the sperm. I would not want any son or daughter of mine taking Accutane for acne, by the way.  I feel the reproductive harm is for both boys and girls ... long after they are done taking this. The warnings look just like that of 2-butoxyethanol AND it has a butylated inert ingredient. I personally believe that we are talking about many generations of chemically poisoned people ... by a chemical which does affect the genes.